Disposal of Unused Promethazine HCl and Codeine Phosphate Oral Remedy Recommend clients to thoroughly eliminate unused promethazine HCl and codeine phosphate oral solution. Advise people to throw the drug while in the house trash adhering to these actions. 1) Take out them from their original containers and blend them with the undesirable material, for example utilised espresso grounds or kitty litter (this tends to make the drug significantly less desirable to small children and Animals, and unrecognizable to those who might intentionally go throughout the trash trying to find prescription drugs).

Neuroleptic malignant syndrome (NMS) which can lead to death. Convey to your healthcare supplier at once In case you have any of the subsequent indicators of NMS:

If this SPL consists of inactivated NDCs detailed through the FDA initiated compliance motion, they will be specified as a result.

eight.seven Hepatic Impairment No formal studies have been carried out in sufferers with hepatic impairment Therefore the pharmacokinetics of promethazine HCl and codeine phosphate oral Answer With this affected individual populace are not known.

Existence-threatening respiratory challenges (respiratory melancholy). Promethazine Hydrochloride and Codeine Phosphate Oral Resolution could potentially cause respiration difficulties (respiratory depression) that could occur Anytime all through procedure and can lead to Dying. Your threat of breathing difficulties is finest if you first start off using Promethazine Hydrochloride and Codeine Phosphate Oral Answer, are getting other medicines that can cause respiration challenges, have particular lung troubles, are aged or have particular other health conditions.

Hemodialysis is not routinely utilised to improve the elimination of codeine or promethazine from the human body.

Lower blood pressure. A unexpected fall in blood pressure can occur in a number of people for the duration of therapy with Promethazine Hydrochloride and Codeine Phosphate Oral Alternative which may possibly result in you to feel dizzy, faint, lightheaded, or weak, especially when you rise up (orthostatic hypotension). Your danger of getting this problem may be enhanced if you are taking Promethazine Hydrochloride and Codeine Phosphate Oral Answer with specified other medicines that decreased blood pressure.

This can be related to a lower in efficacy, and in a few clients, might cause indicators and symptoms of opioid withdrawal.

Treatment of Overdose Remedy of overdosage is pushed by the overall medical presentation, and consists of discontinuation of promethazine HCl and codeine phosphate oral Remedy along with institution of acceptable therapy. Give Most important focus on the reestablishment of suitable respiratory Trade by provision of the patent and guarded airway and also the institution of assisted or controlled air flow.

Propulsive peristaltic waves in the colon are diminished, though tone might be elevated to the point of spasm resulting in constipation. Other opioid-induced outcomes may perhaps include a discount in biliary and pancreatic secretions, spasm of sphincter of Oddi, and transient elevations in serum amylase.

Promethazine HCl and codeine phosphate oral Remedy is not really suggested to be used in pregnant Women of all ages. Extended usage of promethazine HCl and codeine phosphate oral Answer during pregnancy may end up in neonatal opioid withdrawal syndrome, which can be everyday living-threatening Otherwise recognized and dealt with.

Steer clear of the use of promethazine HCl and codeine phosphate oral Remedy in clients who are using inhibitors of CYP2D6.

Reduced hypertension. A unexpected drop in hypertension can come about in a lot of people in the course of cure with Promethazine Hydrochloride and Codeine Phosphate Oral Solution which may possibly trigger you to definitely sense dizzy, faint, lightheaded, or weak, particularly when you get up (orthostatic hypotension). Your hazard of getting this issue could be elevated if you take Promethazine Hydrochloride and Codeine Phosphate Oral Option with particular other medicines that lessen blood pressure level.

In sufferers with circulatory shock, promethazine HCl and codeine phosphate oral Option may trigger vasodilation that will more lessen check here cardiac output and blood pressure level. Steer clear of the use of promethazine HCl and codeine phosphate oral solution in patients with circulatory shock.